Esker card game quotes and pricing

Getting some quotes back from manufacturers. A big variety in price points and discounts. The game is at a minimum 72 cards in a tuckbox, although I have considered extras like a two-piece box and an instructions sheet. I already have an instructions card, but it might be cool to have that be more obvious.

Here's what I have so far for quotes.  Tuck = tuckbox, 2P = two-piece box, I = small instructions sheet.

Some notes:

• Ace (aka PlayingCardsIndia) is coming in at the most economical. They only bid for one print run, so they may have even steeper discounts at higher orders - I just extended their line so that I could see them relative to others. 
• A two-piece box is way more (+$1-2) for some companies and not much more (+$0.50) for others. 
• At a potential retail price point of $12 or $13, assuming I use my own art and don't get it redone, I'd probably be able to cover other costs (advertising, equipment, my time) at the Ace bid, but not necessarily too far above that. I don't want to order too many to start, because it's an unproven product in an industry that I know well as a customer but in which I have very limited experience as a seller. 
• I've checked into selling at Amazon, and for something like this, they'd take about a $3.40 commission per order for just providing a purchase link and collecting orders for me to fulfill, and $7.00 if I have them do the whole fulfillment thing (they warehouse and ship the game, including via Amazon Prime). I'd like a presence on Amazon, but I don't know which option to go with. If I'm paying $5 per game to print, there's almost no margin for the Amazon fulfillment, but if I'm at $2 per game, then I could still make a few bucks that way. If I do the packing and shipping, then the margin is considerably larger, but I lose the Amazon Prime advantage and have to do the work myself, which may include equipment and will include my time (though not likely too much).